USP44

Across TCGA pan-cancer cohorts, USP44 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of USP44’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where USP44 RNA is repressed in tumor relative to normal tissue. In most cancer types USP44 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KICH are the cancer types where USP44 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP44 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.346	<.001	12	view →
LUAD	Male	II,III,IV	−1.648	<.001	11	view →
KICH	Male	All	−1.619	<.001	11	view →
THCA	Male	III,IV	−1.281	<.001	10	view →
LUSC	Female	II,III,IV	−1.872	<.001	8	view →
COAD	All	All	−0.181	<.001	7	view →
BRCA	Female	All	−0.947	<.001	6	view →
KIRP	All	All	−0.649	<.001	4	view →
UCEC	All	All	−0.531	.002	2	view →
READ	Female	All	−0.518	.018	2	view →
PRAD	All	All	−0.465	<.001	2	view →
CHOL	All	All	+0.577	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

USP44–KIRC

Open the KIRC breakdown →