USP44

Across TCGA pan-cancer cohorts, USP44 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated USP44 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP44 RNA is associated with better overall survival. In most high-consensus cancer types, elevated USP44 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, ACC, and UCS are the cancer types where USP44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.847	0.675	.001	69	view →
ACC	DFS	Quartile	II,III,IV	0.303	0.779	<.001	57	view →
UCS	OS	Quartile	II,III,IV	0.661	0.217	.005	38	view →
SCLC	OS	Tertile	II,III,IV	0.164	0.819	<.001	36	view →
MESO	DFS	Median	III,IV	0.301	0.511	.004	31	view →
LUAD	OS	Tertile	All	0.866	0.754	.002	28	view →
KIRC	OS	Quartile	All	0.862	0.740	.002	28	view →
BRCA	OS	Median	III,IV	0.661	0.373	.003	24	view →
SKCM	OS	Median	IV	0.867	0.225	.001	18	view →
GBM	OS	Median	All	0.318	0.218	.006	15	view →
ESCA	OS	Tertile	III,IV	0.655	0.319	.008	14	view →
LGG	OS	Median	All	0.938	0.850	<.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

USP44–HNSC (OS)

Open the HNSC breakdown →