USP43

Across TCGA cell cohorts, USP43 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP43-associated genes across cancer lineages are VN1R2, PRSS58, and OC90. Each is linked with USP43 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP43-to-partner and partner-to-USP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R2 grouped by USP43-low versus USP43-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP43→partner) and Y-score (partner→USP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VN1R2 →	+0.040	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	PRSS58 →	+0.023	+4.643	<.001	.008	3	2
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	2
PANCREAS	TECTB →	+0.983	+4.011	<.001	.009	3	1
LUNG_NSCLC_LUSC	CLRN1 →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TMCO5A →	+0.060	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

VN1R2 by USP43 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →