USP43

Across TCGA pan-cancer cohorts, USP43 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of USP43’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where USP43 RNA is repressed in tumor relative to normal tissue. In most cancer types USP43 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, BLCA, and STAD are the cancer types where USP43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.396	<.001	8	view →
BLCA	All	All	+1.100	.003	8	view →
STAD	Male	All	+1.388	<.001	7	view →
UCEC	All	All	+1.963	<.001	6	view →
KIRC	All	II,III,IV	−0.411	<.001	6	view →
CHOL	All	All	+2.067	<.001	5	view →
HNSC	Male	All	+0.792	<.001	5	view →
BRCA	All	All	+0.430	<.001	4	view →
LIHC	All	All	−0.317	.024	4	view →
LUAD	Male	All	+0.466	.015	3	view →
ESCA	All	All	+0.972	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

USP43–KICH

Open the KICH breakdown →