USP35

Across TCGA patient cohorts, USP35 protein abundance is significantly associated with the RNA expression of many other genes, with 4,032 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible USP35-associated genes across cancer lineages are SORCS1, CPLX1, and SYT13. Each is linked with USP35 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP35-to-partner and partner-to-USP35 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP35 versus SORCS1 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP35→partner) and Y-score (partner→USP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SORCS1 →	+1.237	+0.213	.001	.004	3	3
GBM	CPLX1 →	+1.375	+0.372	<.001	<.001	3	3
BRCA	SYT13 →	+1.696	+0.352	<.001	.004	3	3
BRCA	LYRM9 →	+0.553	+0.379	<.001	.002	3	3
BRCA	C3orf18 →	+0.925	+0.560	<.001	<.001	3	3
HNSC	PTCHD4 →	+1.050	+0.656	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,032 associations by consensus.

USP35 vs SORCS1 — GBM

Explore this scatter interactively →