USP35

Across TCGA pan-cancer cohorts, USP35 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated USP35 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher USP35 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP35 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

KIRC, UCEC, and SKCM are the cancer types where USP35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.538	0.730	<.001	83	view →
UCEC	OS	Median	II,III,IV	0.266	0.765	<.001	64	view →
SKCM	OS	Median	IV	0.365	0.778	.001	56	view →
MESO	OS	Tertile	All	0.274	0.507	.002	51	view →
KICH	OS	Median	II,III,IV	0.636	0.959	.003	48	view →
UVM	OS	Quartile	All	0.446	0.853	.004	39	view →
OV	OS	Median	III,IV	0.262	0.362	<.001	36	view →
CESC	DFS	Median	All	0.453	0.632	.004	32	view →
BRCA	OS	Tertile	III,IV	0.952	0.868	.009	23	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	16	view →
PRAD	DFS	Quartile	All	0.666	0.819	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

USP35–KIRC (DFS)

Open the KIRC breakdown →