USP30

Across TCGA patient cohorts, USP30 mutation is significantly associated with the RNA expression of many other genes, with 2,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP30-associated genes across cancer lineages are RNU6-903P, RN7SL248P, and RNU6-854P. Each is linked with USP30 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP30-to-partner and partner-to-USP30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-903P grouped by USP30-low versus USP30-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP30→partner) and Y-score (partner→USP30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-903P →	+0.597	+5.039	<.001	.008	3	2
UCEC	RN7SL248P →	+0.048	+2.847	<.001	.008	3	2
HNSC	RNU6-854P →	+0.359	+4.320	.006	.007	3	2
HNSC	TBC1D3P4 →	+0.031	+4.505	<.001	.009	3	2
HNSC	MIR583 →	+0.631	+5.111	<.001	.004	3	2
COAD	RNU6-1140P →	+0.456	+5.435	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,061 associations by consensus.

RNU6-903P by USP30 expression — READ

Explore this box plot interactively →