USP30

Across TCGA pan-cancer cohorts, USP30 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of USP30’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where USP30 RNA is repressed in tumor relative to normal tissue. In most cancer types USP30 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, LIHC, and THCA are the cancer types where USP30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.738	<.001	12	view →
LIHC	Male	All	+0.848	<.001	9	view →
THCA	Male	All	−0.522	<.001	9	view →
LUAD	Female	II,III,IV	−0.654	<.001	6	view →
BLCA	Female	III,IV	+0.697	.005	5	view →
BRCA	Female	All	−0.267	<.001	4	view →
UCEC	All	All	−0.577	.001	2	view →
READ	All	III,IV	−0.370	.041	2	view →
KIRC	All	All	+0.166	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

USP30–COAD

Open the COAD breakdown →