USP28

Across TCGA cell cohorts, USP28 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP28-associated genes across cancer lineages are GNAT3, GZMK, and DEFB133. Each is linked with USP28 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP28-to-partner and partner-to-USP28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNAT3 grouped by USP28-low versus USP28-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP28→partner) and Y-score (partner→USP28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GNAT3 →	+0.043	+3.584	.002	.004	3	2
BLOOD_Leukemia	GZMK →	+0.579	+4.037	<.001	.004	3	2
CNS	DEFB133 →	+0.035	+5.357	<.001	.001	3	2
STOMACH	VSTM1 →	+1.189	+3.736	<.001	.006	3	2
BLOOD_Myeloma	SMIM36 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPRR5 →	+0.320	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

GNAT3 by USP28 expression — BLOOD_Lymphoma

Explore this box plot interactively →