USP28

Across TCGA pan-cancer cohorts, USP28 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of USP28’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where USP28 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP28 is over-expressed in tumor.

LUAD, LIHC, and HNSC are the cancer types where USP28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.669	<.001	7	view →
LIHC	Male	All	+0.603	<.001	7	view →
HNSC	All	II,III,IV	+0.437	.003	6	view →
LUSC	Male	II,III,IV	+1.037	<.001	5	view →
CHOL	Male	All	+1.175	.001	4	view →
STAD	Male	II,III,IV	+0.756	.004	2	view →
ESCA	Female	All	+0.726	.015	2	view →
KIRP	All	IV	+0.557	.009	2	view →
COAD	Male	All	+0.330	.009	2	view →
KICH	All	All	+0.353	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

USP28–LUAD

Open the LUAD breakdown →