USP28

Across TCGA pan-cancer cohorts, USP28 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated USP28 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher USP28 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP28 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

ACC, LGG, and KIRC are the cancer types where USP28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.267	0.632	<.001	89	view →
LGG	OS	Median	All	0.360	0.537	<.001	53	view →
KIRC	OS	Median	All	0.907	0.839	.002	52	view →
READ	DFS	Median	All	0.712	0.277	.001	44	view →
UCS	DFS	Median	IV	0.952	0.367	.001	42	view →
MESO	DFS	Quartile	II,III,IV	0.343	0.547	.024	36	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	31	view →
HNSC	DFS	Tertile	IV	0.503	0.275	<.001	30	view →
GBM	DFS	Tertile	All	0.502	0.159	<.001	24	view →
DLBC	DFS	Tertile	All	0.480	0.984	.022	19	view →
LIHC	OS	Quartile	All	0.642	0.831	.004	18	view →
SARC	OS	Median	All	0.663	0.855	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

USP28–ACC (DFS)

Open the ACC breakdown →