USP16

Across TCGA cell cohorts, USP16 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP16-associated genes across cancer lineages are AVP, KRTAP1-1, and KRTAP4-1. Each is linked with USP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP16-to-partner and partner-to-USP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by USP16-low versus USP16-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP16→partner) and Y-score (partner→USP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP1-1 →	+0.068	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	CSN1S1 →	+0.021	+4.887	.003	.009	3	1
LUNG_NSCLC_LUAD	OR8D4 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	DUSP21 →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

AVP by USP16 expression — BLOOD_Lymphoma

Explore this box plot interactively →