USP16

Across TCGA pan-cancer cohorts, USP16 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of USP16’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where USP16 RNA is repressed in tumor relative to normal tissue. In most cancer types USP16 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where USP16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.190	<.001	11	view →
LIHC	All	All	+0.566	<.001	7	view →
KICH	Female	All	−0.947	<.001	6	view →
LUAD	Female	II,III,IV	−0.322	.006	4	view →
CHOL	All	All	+1.018	<.001	2	view →
UCEC	All	All	−0.651	<.001	2	view →
KIRP	Male	All	−0.558	<.001	2	view →
COAD	All	All	−0.314	.023	2	view →
ESCA	Female	All	+0.493	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

USP16–THCA

Open the THCA breakdown →