UNC13A

Across TCGA patient cohorts, UNC13A mutation is significantly associated with the RNA expression of many other genes, with 7,058 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UNC13A-associated genes across cancer lineages are RPL23AP82, FEN1, and SNRPD1. Each is linked with UNC13A in more than 4 cancer types. Because this analysis shows association rather than direction, both UNC13A-to-partner and partner-to-UNC13A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by UNC13A-low versus UNC13A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UNC13A→partner) and Y-score (partner→UNC13A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.514	+2.010	<.001	<.001	3	5
UCEC	FEN1 →	+0.764	+2.269	<.001	<.001	3	5
UCEC	SNRPD1 →	+0.489	+2.010	<.001	<.001	3	5
UCEC	CENPX →	+0.457	+2.534	<.001	<.001	3	5
UCEC	TYMSOS →	+0.951	+2.534	<.001	<.001	3	5
UCEC	TIPIN →	+0.676	+4.269	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,058 associations by consensus.

RPL23AP82 by UNC13A expression — UCEC

Explore this box plot interactively →