UNC13A

Across TCGA pan-cancer cohorts, UNC13A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UNC13A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UNC13A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UNC13A is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

HNSC, BRCA, and LIHC are the cancer types where UNC13A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UNC13A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.120	<.001	10	view →
BRCA	Female	II,III,IV	+0.460	<.001	8	view →
LIHC	All	All	+0.174	<.001	7	view →
LUAD	All	All	+0.370	.005	4	view →
STAD	Male	II,III,IV	+0.304	.006	4	view →
CHOL	Male	All	+0.203	.003	3	view →
LUSC	All	II,III,IV	+0.340	.044	2	view →
KIRC	All	All	+0.129	.014	2	view →
READ	Female	All	−0.326	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UNC13A–HNSC

Open the HNSC breakdown →