UNC13A

Across TCGA pan-cancer cohorts, UNC13A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated UNC13A data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher UNC13A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UNC13A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

KIRP, HNSC, and LUSC are the cancer types where UNC13A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.461	0.814	<.001	64	view →
HNSC	DFS	Quartile	IV	0.735	0.535	.003	48	view →
LUSC	DFS	Quartile	II,III,IV	0.528	0.742	.003	40	view →
LGG	DFS	Median	All	0.801	0.674	<.001	36	view →
PAAD	DFS	Median	All	0.394	0.175	<.001	34	view →
ACC	DFS	Quartile	All	0.197	0.922	<.001	33	view →
THCA	OS	Median	II,III,IV	0.745	0.963	.001	30	view →
UCS	OS	Median	All	0.418	0.712	.006	26	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	15	view →
READ	DFS	Quartile	II,III,IV	0.926	0.615	.014	14	view →
SKCM	DFS	Median	II,III,IV	0.399	0.216	.005	14	view →
SCLC	DFS	Tertile	II,III,IV	0.877	0.247	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

UNC13A–KIRP (DFS)

Open the KIRP breakdown →