UBQLN3

Across TCGA cell cohorts, UBQLN3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible UBQLN3-associated genes across cancer lineages are C2orf80, OR4N4, and PNLIPRP1. Each is linked with UBQLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLN3-to-partner and partner-to-UBQLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf80 grouped by UBQLN3-low versus UBQLN3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN3→partner) and Y-score (partner→UBQLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C2orf80 →	+0.055	+4.209	.003	.006	3	1
LUNG_SCLC	OR4N4 →	+0.103	+2.847	<.001	.009	3	1
LUNG_SCLC	PNLIPRP1 →	+0.039	+3.421	<.001	<.001	3	1
LUNG_SCLC	APOC4 →	+0.029	+2.847	<.001	.009	3	1
LARGE_INTESTINE	TBC1D3 →	+0.057	+2.688	<.001	.008	3	1
STOMACH	BMP15 →	+0.032	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

C2orf80 by UBQLN3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →