UBQLN3

Across TCGA pan-cancer cohorts, UBQLN3 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated UBQLN3 data layer compared with 7 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher UBQLN3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBQLN3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and TGCT show a favorable association.

DLBC, LUAD, and GBM are the cancer types where UBQLN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	II,III,IV	0.320	0.828	.002	30	view →
LUAD	DFS	Tertile	IV	0.671	0.893	.019	21	view →
GBM	OS	Tertile	All	0.096	0.428	<.001	18	view →
STAD	OS	Tertile	All	0.595	0.769	.040	18	view →
SCLC	DFS	Tertile	All	0.274	0.815	.013	18	view →
THCA	OS	Tertile	III,IV	0.240	0.795	.039	9	view →
KIRC	DFS	Tertile	III,IV	0.821	0.720	.033	6	view →
TGCT	DFS	Tertile	All	0.812	0.666	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

UBQLN3–DLBC (DFS)

Open the DLBC breakdown →