UBQLN3

Across TCGA pan-cancer cohorts, UBQLN3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UBQLN3’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where UBQLN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBQLN3 is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.

BRCA, THCA, and LUSC are the cancer types where UBQLN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBQLN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	+0.007	.042	2	view →
THCA	Female	III,IV	+0.015	.024	1	view →
LUSC	All	II,III,IV	−0.009	.049	1	view →
KIRC	All	IV	−0.006	.019	1	view →
LIHC	All	All	+0.002	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UBQLN3–BRCA

Open the BRCA breakdown →