UBA7

Across TCGA cell cohorts, UBA7 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBA7-associated genes across cancer lineages are USP17L11, USP17L20, and USP17L18. Each is linked with UBA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA7-to-partner and partner-to-UBA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L11 grouped by UBA7-low versus UBA7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA7→partner) and Y-score (partner→UBA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP17L11 →	+0.012	+3.684	<.001	<.001	3	2
BLOOD_Leukemia	USP17L20 →	+0.003	+3.802	<.001	.001	3	2
BLOOD_Leukemia	USP17L18 →	+0.003	+3.802	<.001	.001	3	2
KIDNEY	CEBPE →	+0.007	+4.491	<.001	.002	3	1
SOFT_TISSUE	KLK12 →	+0.821	+4.930	<.001	.008	3	1
SOFT_TISSUE	DYTN →	+0.016	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

USP17L11 by UBA7 expression — BLOOD_Leukemia

Explore this box plot interactively →