UBA7

Across TCGA pan-cancer cohorts, UBA7 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated UBA7 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher UBA7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated UBA7 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, BLCA, and BRCA are the cancer types where UBA7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.433	0.249	<.001	155	view →
BLCA	OS	Tertile	II,III,IV	0.795	0.640	<.001	81	view →
BRCA	OS	Tertile	II,III,IV	0.545	0.496	.001	63	view →
LGG	DFS	Median	All	0.245	0.487	<.001	53	view →
KIRC	DFS	Quartile	All	0.719	0.853	.001	34	view →
HNSC	DFS	Quartile	All	0.508	0.246	<.001	23	view →
CESC	DFS	Tertile	All	0.903	0.771	.002	18	view →
MESO	OS	Quartile	All	0.396	0.816	.026	12	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
READ	DFS	Quartile	II,III,IV	0.909	0.189	.023	9	view →
SARC	OS	Median	All	0.844	0.677	.007	9	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

UBA7–SKCM (OS)

Open the SKCM breakdown →