TYSND1

Across TCGA patient cohorts, TYSND1 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYSND1-associated genes across cancer lineages are ATF4P1, VDAC1P12, and CXCL1P1. Each is linked with TYSND1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TYSND1-to-partner and partner-to-TYSND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P1 grouped by TYSND1-low versus TYSND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYSND1→partner) and Y-score (partner→TYSND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P1 →	+0.078	+2.910	<.001	.004	3	3
CESC	VDAC1P12 →	+0.061	+5.969	<.001	.002	3	2
CESC	CXCL1P1 →	+0.234	+5.669	<.001	.003	3	2
UCEC	SALL4P5 →	+0.070	+2.550	<.001	.006	3	2
CESC	OR5G5P →	+0.113	+5.201	<.001	.007	3	1
CESC	RNU6-432P →	+0.428	+6.144	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

ATF4P1 by TYSND1 expression — UCEC

Explore this box plot interactively →