Q-omics provides the consensus-scored ATF4P1 profile across patient tissues and cancer cell-line models. ATF4P1 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, ATF4P1 is differentially expressed in 3, with the highest sampling consensus in LUAD. Additionally, ATF4P1 RNA expression shows 3,713 significant protein co-abundance associations, with the highest sampling consensus in OV. Together, these results highlight MESO, LUAD, and OV as cancer lineages where ATF4P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ATF4P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ATF4P1 survival associations across molecular data types. ATF4P1 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ATF4P1 RNA expression–survival associations across cancer types. High ATF4P1 expression shows unfavorable associations in KIRP, BRCA, COAD, LUAD and THYM, but favorable associations in MESO. The MESO Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .004). Together, the overview and detailed table identify MESO as the clearest survival context for ATF4P1 RNA expression.
This table summarizes ATF4P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for ATF4P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ATF4P1 shows lower tumor expression in LUAD and HNSC and higher tumor expression in LUSC. The LUAD box plot shows higher ATF4P1 RNA expression in normal versus tumor tissue (log2 FC = −0.060, t-test p = .002).
This table shows molecular features associated with ATF4P1 in patient tissues and cancer cell lines. In patient samples, ATF4P1 shows the broadest associations at the RNA and protein expression levels, with OV recurring as the lineage with the largest associated feature set.
