TYSND1

Across TCGA pan-cancer cohorts, TYSND1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TYSND1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TYSND1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TYSND1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where TYSND1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYSND1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.833	<.001	10	view →
HNSC	All	All	+0.553	<.001	10	view →
LIHC	Female	II,III,IV	+1.439	<.001	9	view →
STAD	All	II,III,IV	+0.875	<.001	9	view →
LUSC	Female	II,III,IV	+1.248	<.001	8	view →
THCA	Male	III,IV	−0.538	<.001	8	view →
LUAD	Male	All	+0.537	<.001	8	view →
KICH	Female	All	−0.810	<.001	6	view →
BLCA	All	All	+0.698	.002	5	view →
UCEC	All	All	+0.473	.009	4	view →
CHOL	All	All	+1.826	<.001	3	view →
KIRP	All	IV	+0.560	.023	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TYSND1–COAD

Open the COAD breakdown →