TYRO3

Across TCGA patient cohorts, TYRO3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,780 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TYRO3-associated genes across cancer lineages are IMPDH2, CRISPLD2, and BIN2. Each is linked with TYRO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TYRO3-to-partner and partner-to-TYRO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TYRO3 versus IMPDH2 in HNSC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRO3→partner) and Y-score (partner→TYRO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IMPDH2 →	-0.953	-0.508	<.001	.001	3	4
OV	CRISPLD2 →	+1.115	+0.401	.007	.003	3	3
OV	BIN2 →	+0.797	+0.412	.002	.002	3	3
GBM	MAN1C1 →	+0.862	+0.375	<.001	<.001	3	3
HNSC	PTPN22 →	+0.926	+0.491	<.001	<.001	3	3
HNSC	PARVG →	+0.727	+0.473	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,780 associations by consensus.

TYRO3 vs IMPDH2 — HNSC

Explore this scatter interactively →