TYRO3

Across TCGA pan-cancer cohorts, TYRO3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TYRO3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TYRO3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TYRO3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where TYRO3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYRO3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.860	<.001	11	view →
THCA	Female	III,IV	+1.171	<.001	10	view →
LIHC	Female	II,III,IV	+1.621	<.001	8	view →
KIRC	Male	All	−1.084	<.001	8	view →
KIRP	Male	All	−1.576	<.001	7	view →
UCEC	All	II,III,IV	−1.851	<.001	6	view →
BRCA	All	II,III,IV	−1.364	<.001	6	view →
BLCA	Male	All	+0.989	.002	6	view →
LUSC	Male	All	+0.866	<.001	6	view →
CHOL	All	All	+3.046	<.001	5	view →
HNSC	Female	All	−0.747	.010	5	view →
READ	All	All	+0.786	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TYRO3–COAD

Open the COAD breakdown →