TYRO3

Across TCGA pan-cancer cohorts, TYRO3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TYRO3 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TYRO3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TYRO3 expression acts as an unfavorable survival marker, although some lineages such as UCS and THCA show a favorable association.

KIRP, ACC, and LIHC are the cancer types where TYRO3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.781	0.925	<.001	168	view →
ACC	DFS	Median	All	0.222	0.681	<.001	95	view →
LIHC	OS	Median	All	0.605	0.802	<.001	66	view →
BLCA	DFS	Tertile	All	0.254	0.450	.003	49	view →
KICH	DFS	Tertile	All	0.713	1.000	.005	36	view →
KIRC	DFS	Tertile	II,III,IV	0.684	0.877	.002	35	view →
UVM	DFS	Median	II,III,IV	0.584	0.862	.004	34	view →
COAD	DFS	Tertile	III,IV	0.598	0.796	.005	29	view →
UCS	DFS	Median	III,IV	0.521	0.152	.003	28	view →
STAD	OS	Quartile	All	0.451	0.795	.012	24	view →
THCA	OS	Tertile	All	1.000	0.738	.006	18	view →
ESCA	DFS	Median	All	0.458	0.273	.024	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TYRO3–KIRP (DFS)

Open the KIRP breakdown →