TULP3

Across TCGA patient cohorts, TULP3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TULP3-associated genes across cancer lineages are Rad50, S6_pS240_S244, and SF2. Each is linked with TULP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TULP3-to-partner and partner-to-TULP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by TULP3-low versus TULP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TULP3→partner) and Y-score (partner→TULP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.350	-2.459	.002	.020	3	1
UCEC	S6_pS240_S244 →	+0.555	+3.013	.004	.018	3	1
UCEC	SF2 →	+0.122	+2.834	.021	.034	3	1
UCEC	TIGAR →	+0.180	+3.000	.014	.036	3	1
UCEC	ATM →	-0.716	-3.156	.001	.018	3	1
UCEC	PRDX1 →	+0.201	+3.169	.043	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Rad50 by TULP3 expression — UCEC

Explore this box plot interactively →