TUBG2

Across TCGA cell cohorts, TUBG2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TUBG2-associated genes across cancer lineages are ADGRE3, OR4E2, and RNASE9. Each is linked with TUBG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBG2-to-partner and partner-to-TUBG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRE3 grouped by TUBG2-low versus TUBG2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBG2→partner) and Y-score (partner→TUBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADGRE3 →	+0.040	+5.000	<.001	.005	3	1
BREAST	OR4E2 →	+0.025	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LCE1C →	+0.079	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PNMA6F →	+0.006	+4.887	.009	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+4.977	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ADGRE3 by TUBG2 expression — KIDNEY

Explore this box plot interactively →