TUBG2

Across TCGA pan-cancer cohorts, TUBG2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TUBG2 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TUBG2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUBG2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

COAD, LIHC, and OV are the cancer types where TUBG2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.435	0.679	<.001	72	view →
LIHC	DFS	Median	All	0.462	0.616	<.001	64	view →
OV	OS	Tertile	III,IV	0.779	0.894	.001	56	view →
UVM	OS	Tertile	All	0.519	0.956	.002	55	view →
LUAD	OS	Tertile	III,IV	0.649	0.191	.008	39	view →
CESC	DFS	Quartile	All	0.779	0.929	.001	32	view →
PAAD	DFS	Median	All	0.452	0.277	.001	27	view →
LAML	DFS	Median	All	0.473	0.665	.004	20	view →
LGG	OS	Tertile	All	0.603	0.388	.003	18	view →
STAD	DFS	Tertile	II,III,IV	0.448	0.631	.017	17	view →
PRAD	DFS	Median	All	0.906	0.959	.001	12	view →
ESCA	OS	Tertile	All	1.000	0.508	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TUBG2–COAD (DFS)

Open the COAD breakdown →