TUBG2

Across TCGA pan-cancer cohorts, TUBG2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TUBG2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TUBG2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TUBG2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where TUBG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.008	<.001	12	view →
LIHC	Female	II,III,IV	+1.471	<.001	9	view →
KICH	All	All	−0.883	<.001	6	view →
BRCA	Female	All	−0.785	<.001	6	view →
CHOL	Female	All	+2.840	<.001	5	view →
BLCA	Male	III,IV	−1.285	.009	4	view →
LUAD	All	All	−0.272	.004	3	view →
UCEC	All	All	−0.898	<.001	2	view →
PRAD	All	All	−0.785	<.001	2	view →
PAAD	All	All	+0.530	.041	2	view →
THCA	Male	III,IV	−0.381	.014	2	view →
COAD	Female	All	+0.467	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TUBG2–HNSC

Open the HNSC breakdown →