TTK

Across TCGA cell cohorts, TTK mutation is significantly associated with the RNA expression of many other genes, with 890 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTK-associated genes across cancer lineages are EDDM3A, ODF4, and MS4A12. Each is linked with TTK in more than 1 cancer types. Because this analysis shows association rather than direction, both TTK-to-partner and partner-to-TTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDDM3A grouped by TTK-low versus TTK-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTK→partner) and Y-score (partner→TTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EDDM3A →	+0.060	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	ODF4 →	+0.046	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	MS4A12 →	+0.103	+4.643	<.001	.008	3	2
LARGE_INTESTINE	FAM149A →	+1.008	+2.389	.002	.006	3	2
LARGE_INTESTINE	PRDM4 →	+0.467	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	ATF2 →	+0.359	+1.949	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 890 associations by consensus.

EDDM3A by TTK expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →