TTK

Across TCGA pan-cancer cohorts, TTK RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of TTK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTK is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where TTK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.835	<.001	12	view →
KIRC	All	IV	+0.933	<.001	12	view →
BLCA	Male	III,IV	+3.255	<.001	11	view →
LUAD	Male	III,IV	+2.815	<.001	11	view →
KIRP	All	III,IV	+1.490	<.001	11	view →
STAD	Female	All	+2.538	<.001	10	view →
LUSC	Female	II,III,IV	+3.717	<.001	9	view →
LIHC	Male	All	+1.493	<.001	9	view →
COAD	Male	III,IV	+1.310	<.001	9	view →
UCEC	All	II,III,IV	+3.189	<.001	8	view →
BRCA	All	II,III,IV	+2.120	<.001	6	view →
READ	All	All	+0.956	.005	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

TTK–HNSC

Open the HNSC breakdown →