TTK

Across TCGA pan-cancer cohorts, TTK RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TTK data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TTK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TTK expression acts as an unfavorable survival marker, although some lineages such as GBM and UCS show a favorable association.

KIRP, ACC, and MESO are the cancer types where TTK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.516	0.782	<.001	150	view →
ACC	OS	Median	All	0.399	0.801	<.001	149	view →
MESO	OS	Median	All	0.362	0.720	<.001	138	view →
LIHC	DFS	Median	All	0.455	0.625	<.001	111	view →
KICH	DFS	Median	II,III,IV	0.568	0.954	.001	97	view →
KIRC	DFS	Quartile	All	0.673	0.847	.001	60	view →
LGG	OS	Median	All	0.734	0.895	<.001	51	view →
UCEC	DFS	Tertile	All	0.587	0.844	<.001	48	view →
PAAD	OS	Quartile	All	0.247	0.590	<.001	48	view →
BRCA	DFS	Tertile	IV	0.206	0.800	.005	43	view →
SARC	DFS	Tertile	All	0.512	0.733	<.001	34	view →
LUAD	OS	Median	All	0.612	0.753	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TTK–KIRP (OS)

Open the KIRP breakdown →