TTI2

Across TCGA cell cohorts, TTI2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTI2-associated genes across cancer lineages are ACSM6, GHRHR, and OTOS. Each is linked with TTI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTI2-to-partner and partner-to-TTI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by TTI2-low versus TTI2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI2→partner) and Y-score (partner→TTI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
BLOOD_Leukemia	GHRHR →	+0.407	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OTOS →	+0.039	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CASP12 →	+0.358	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ACSM6 by TTI2 expression — LARGE_INTESTINE

Explore this box plot interactively →