TTI2

Across TCGA pan-cancer cohorts, TTI2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TTI2 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TTI2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTI2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

MESO, KIRC, and LIHC are the cancer types where TTI2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.276	0.445	.002	66	view →
KIRC	DFS	Tertile	All	0.733	0.484	<.001	60	view →
LIHC	OS	Quartile	All	0.611	0.823	.002	55	view →
OV	DFS	Quartile	III,IV	0.607	0.471	.009	50	view →
ACC	DFS	Median	All	0.269	0.615	<.001	44	view →
KIRP	OS	Median	II,III,IV	0.311	0.916	.004	40	view →
HNSC	DFS	Tertile	IV	0.744	0.368	.001	30	view →
COAD	OS	Tertile	All	0.745	0.422	.003	16	view →
THYM	OS	Median	All	0.960	0.785	.007	15	view →
KICH	DFS	Quartile	All	0.603	0.938	.031	11	view →
LUAD	DFS	Quartile	All	0.671	0.854	.009	9	view →
LUSC	DFS	Median	IV	0.827	0.134	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TTI2–MESO (DFS)

Open the MESO breakdown →