TTI2

Across TCGA pan-cancer cohorts, TTI2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TTI2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTI2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTI2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where TTI2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTI2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.600	<.001	11	view →
THCA	Male	III,IV	−0.558	<.001	10	view →
KICH	All	All	−0.663	<.001	6	view →
BRCA	All	III,IV	+0.646	<.001	6	view →
STAD	All	II,III,IV	+0.599	<.001	6	view →
LUSC	All	II,III,IV	+0.498	<.001	5	view →
READ	Male	All	+0.686	.021	4	view →
LUAD	Male	II,III,IV	+0.395	.003	4	view →
COAD	All	All	+0.288	.006	4	view →
CHOL	Female	All	+1.100	<.001	3	view →
ESCA	Female	All	+0.763	.032	2	view →
UCEC	All	III,IV	+0.748	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TTI2–HNSC

Open the HNSC breakdown →