TTC21A

Across TCGA patient cohorts, TTC21A RNA expression is significantly associated with the protein abundance of many other proteins, with 15,893 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TTC21A-associated proteins across cancer lineages are LZTFL1, TTC21B, and APPL1. Each is linked with TTC21A in more than 6 cancer types. Because this analysis shows association rather than direction, both TTC21A-to-partner and partner-to-TTC21A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TTC21A versus LZTFL1 in BRCA, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21A→partner) and Y-score (partner→TTC21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LZTFL1 →	+0.534	+0.650	<.001	<.001	3	7
BRCA	TTC21B →	+0.324	+0.640	<.001	<.001	3	6
HNSC	APPL1 →	+0.263	+0.575	<.001	<.001	3	6
LSCC	NIFK →	-0.375	-0.476	<.001	<.001	3	6
BRCA	SORBS1 →	+0.519	+0.495	<.001	<.001	3	6
BRCA	DDX21 →	-0.563	-0.535	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,893 associations by consensus.

TTC21A vs LZTFL1 — BRCA

Explore this scatter interactively →