TTC21A

Across TCGA pan-cancer cohorts, TTC21A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TTC21A data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTC21A RNA is associated with better overall survival. In most high-consensus cancer types, elevated TTC21A expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, KIRC, and BRCA are the cancer types where TTC21A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.730	0.594	<.001	138	view →
KIRC	DFS	Tertile	IV	0.137	0.404	.001	91	view →
BRCA	OS	Quartile	II,III,IV	0.979	0.919	<.001	79	view →
UVM	OS	Tertile	All	0.897	0.524	<.001	75	view →
ACC	DFS	Quartile	All	0.293	0.770	<.001	67	view →
SKCM	DFS	Quartile	II,III,IV	0.652	0.396	<.001	58	view →
LUSC	DFS	Tertile	II,III,IV	0.631	0.816	.002	48	view →
PAAD	DFS	Tertile	All	0.641	0.334	.001	48	view →
KIRP	DFS	Tertile	All	0.967	0.847	.001	36	view →
UCEC	OS	Quartile	All	0.965	0.865	<.001	36	view →
KICH	DFS	Median	II,III,IV	0.591	1.000	.003	35	view →
LGG	DFS	Median	All	0.296	0.453	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TTC21A–HNSC (OS)

Open the HNSC breakdown →