TTC21A

Across TCGA pan-cancer cohorts, TTC21A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TTC21A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TTC21A RNA is repressed in tumor relative to normal tissue. In most cancer types TTC21A is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LIHC are the cancer types where TTC21A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC21A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.003	<.001	10	view →
LUAD	All	II,III,IV	−0.703	<.001	8	view →
LIHC	All	All	+0.179	<.001	7	view →
LUSC	Female	II,III,IV	−1.575	<.001	6	view →
THCA	All	All	−0.333	<.001	5	view →
COAD	Male	II,III,IV	+0.233	.019	5	view →
HNSC	All	II,III,IV	−0.333	.007	4	view →
CHOL	Male	All	+1.143	<.001	3	view →
BLCA	Female	IV	+1.223	.005	1	view →
KIRP	All	All	+0.364	.019	1	view →
STAD	All	II,III,IV	+0.315	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TTC21A–KICH

Open the KICH breakdown →