TSSK6

Across TCGA patient cohorts, TSSK6 mutation is significantly associated with the RNA expression of many other genes, with 1,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSSK6-associated genes across cancer lineages are RNU6-383P, SENP3-EIF4A1, and ECHS1. Each is linked with TSSK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSK6-to-partner and partner-to-TSSK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-383P grouped by TSSK6-low versus TSSK6-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSK6→partner) and Y-score (partner→TSSK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-383P →	+0.368	+7.977	<.001	.007	3	2
UCEC	SENP3-EIF4A1 →	+0.128	+3.852	<.001	<.001	3	2
STAD	ECHS1 →	+0.521	+3.203	.008	.009	3	2
STAD	FDXR →	+1.038	+3.203	<.001	.009	3	2
STAD	WDR41 →	+0.546	+3.203	.001	.009	3	2
STAD	FUT10 →	+0.916	+3.203	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,506 associations by consensus.

RNU6-383P by TSSK6 expression — LGG

Explore this box plot interactively →