TSSK6

Across TCGA pan-cancer cohorts, TSSK6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TSSK6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSSK6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSSK6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where TSSK6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSSK6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.905	<.001	11	view →
BLCA	Male	All	+1.227	<.001	10	view →
COAD	Male	III,IV	+1.018	<.001	10	view →
LIHC	Female	II,III,IV	+1.121	<.001	9	view →
THCA	Male	II,III,IV	−0.781	<.001	8	view →
KIRC	All	All	+0.280	.001	8	view →
BRCA	All	II,III,IV	+0.361	<.001	6	view →
CHOL	All	All	+1.723	<.001	5	view →
LUSC	Male	II,III,IV	+0.694	<.001	5	view →
STAD	All	II,III,IV	+0.615	<.001	5	view →
KIRP	All	II,III,IV	+0.549	.005	4	view →
READ	All	All	+0.777	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TSSK6–HNSC

Open the HNSC breakdown →