TSSK6

Across TCGA pan-cancer cohorts, TSSK6 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TSSK6 data layer compared with 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSSK6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TSSK6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, SCLC, and KICH are the cancer types where TSSK6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.810	0.671	<.001	141	view →
SCLC	OS	Median	II,III,IV	0.661	0.198	<.001	87	view →
KICH	OS	Median	All	0.610	1.000	<.001	43	view →
PAAD	DFS	Tertile	All	0.398	0.195	.016	35	view →
ACC	DFS	Tertile	All	0.379	0.719	.002	34	view →
LGG	DFS	Tertile	All	0.286	0.456	<.001	32	view →
UCEC	OS	Tertile	IV	0.774	0.278	.001	32	view →
KIRP	DFS	Tertile	IV	0.035	0.621	.004	29	view →
COAD	DFS	Tertile	IV	0.268	0.701	.022	21	view →
STAD	OS	Median	All	0.733	0.599	.007	19	view →
UCS	DFS	Median	IV	0.885	0.440	.015	18	view →
READ	DFS	Tertile	II,III,IV	0.221	0.790	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TSSK6–HNSC (OS)

Open the HNSC breakdown →