TSR1

Across TCGA patient cohorts, TSR1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,199 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TSR1-associated proteins across cancer lineages are MCM4, MCM7, and SUPT16H. Each is linked with TSR1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TSR1-to-partner and partner-to-TSR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSR1 versus MCM4 in GBM, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TSR1→partner) and Y-score (partner→TSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM4 →	+0.618	+0.283	<.001	.004	3	8
GBM	MCM7 →	+0.583	+0.306	<.001	.002	3	8
HNSC	SUPT16H →	+0.425	+0.897	<.001	.003	3	7
UCEC	NCAPH →	+0.704	+0.745	<.001	.001	3	7
LSCC	PUS7 →	+0.506	+0.638	<.001	<.001	3	7
HNSC	WDHD1 →	+0.565	+1.172	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,199 associations by consensus.

TSR1 vs MCM4 — GBM

Explore this scatter interactively →