TSR1

Across TCGA pan-cancer cohorts, TSR1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TSR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSR1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where TSR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.687	<.001	12	view →
COAD	Male	IV	+1.268	<.001	11	view →
KIRC	Female	III,IV	+0.714	<.001	11	view →
KIRP	All	II,III,IV	+0.991	<.001	9	view →
LUAD	Male	II,III,IV	+0.813	<.001	9	view →
LUSC	Male	III,IV	+1.040	<.001	7	view →
STAD	All	II,III,IV	+0.729	.002	6	view →
THCA	All	All	−0.249	.002	6	view →
CHOL	Male	All	+2.260	<.001	5	view →
KICH	Female	II,III,IV	−1.081	<.001	5	view →
LIHC	Female	II,III,IV	+0.851	<.001	5	view →
READ	All	III,IV	+1.105	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TSR1–HNSC

Open the HNSC breakdown →