TSPY2

Across TCGA patient cohorts, TSPY2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TSPY2-associated genes across cancer lineages are LINC02659, RN7SL398P, and MT-TN. Each is linked with TSPY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPY2-to-partner and partner-to-TSPY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02659 grouped by TSPY2-low versus TSPY2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPY2→partner) and Y-score (partner→TSPY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02659 →	+0.137	+4.163	<.001	.003	3	1
SKCM	RN7SL398P →	+0.105	+4.385	<.001	.008	3	1
HNSC	MT-TN →	+0.346	+4.822	<.001	.006	3	1
LUSC	RNU6-1249P →	+0.263	+6.327	<.001	<.001	3	1
LUSC	MIR586 →	+0.289	+5.733	<.001	.001	3	1
LUSC	RNA5SP53 →	+0.322	+4.815	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

LINC02659 by TSPY2 expression — SKCM

Explore this box plot interactively →