TSPAN32

Across TCGA patient cohorts, TSPAN32 mutation is significantly associated with the RNA expression of many other genes, with 1,953 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN32-associated genes across cancer lineages are PPP1R8, PCMT1, and TAF12. Each is linked with TSPAN32 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN32-to-partner and partner-to-TSPAN32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R8 grouped by TSPAN32-low versus TSPAN32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN32→partner) and Y-score (partner→TSPAN32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R8 →	+0.375	+2.137	.005	.009	3	2
UCEC	PCMT1 →	+0.430	+1.936	.004	.003	3	2
UCEC	TAF12 →	+0.434	+2.095	<.001	.003	3	2
UCEC	SLC35B1 →	+0.386	+2.455	.001	.001	3	2
UCEC	DNAJC8 →	+0.381	+2.338	.001	.003	3	2
UCEC	FAM98C →	+0.328	+2.354	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,953 associations by consensus.

PPP1R8 by TSPAN32 expression — UCEC

Explore this box plot interactively →