TSPAN32

Across TCGA pan-cancer cohorts, TSPAN32 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TSPAN32 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSPAN32 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TSPAN32 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where TSPAN32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.758	0.610	<.001	140	view →
SKCM	OS	Median	All	0.409	0.274	<.001	94	view →
LUAD	OS	Tertile	All	0.472	0.285	<.001	48	view →
ESCA	DFS	Tertile	III,IV	0.605	0.288	.005	43	view →
CESC	OS	Tertile	All	0.875	0.692	<.001	38	view →
LIHC	DFS	Tertile	All	0.533	0.336	<.001	34	view →
UCS	DFS	Tertile	IV	0.885	0.250	.024	24	view →
THCA	OS	Tertile	II,III,IV	0.902	1.000	.004	22	view →
CHOL	DFS	Median	All	0.678	0.128	.001	21	view →
KIRC	DFS	Quartile	All	0.487	0.695	.008	20	view →
PRAD	DFS	Median	All	0.716	0.822	<.001	18	view →
LAML	DFS	Tertile	All	0.489	0.682	.021	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TSPAN32–HNSC (OS)

Open the HNSC breakdown →