TSKU

Across TCGA patient cohorts, TSKU mutation is significantly associated with the RNA expression of many other genes, with 3,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSKU-associated genes across cancer lineages are RN7SL498P, RNU6-451P, and RNA5SP419. Each is linked with TSKU in more than 2 cancer types. Because this analysis shows association rather than direction, both TSKU-to-partner and partner-to-TSKU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL498P grouped by TSKU-low versus TSKU-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSKU→partner) and Y-score (partner→TSKU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL498P →	+0.171	+4.684	.009	.004	3	3
LUSC	RNU6-451P →	+0.536	+4.781	<.001	.003	3	2
LUSC	RNA5SP419 →	+0.664	+6.102	<.001	.001	3	2
LUSC	RNA5SP413 →	+0.737	+5.081	<.001	.004	3	2
LUSC	RNA5SP416 →	+0.978	+5.733	<.001	.001	3	2
LUSC	RNA5SP420 →	+0.581	+5.309	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,739 associations by consensus.

RN7SL498P by TSKU expression — LUSC

Explore this box plot interactively →