TSKU

Across TCGA pan-cancer cohorts, TSKU RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated TSKU data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TSKU RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSKU expression acts as an unfavorable survival marker, although some lineages such as UVM and DLBC show a favorable association.

KIRC, UVM, and ACC are the cancer types where TSKU RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.501	0.690	<.001	89	view →
UVM	DFS	Tertile	III,IV	0.925	0.324	<.001	81	view →
ACC	DFS	Tertile	All	0.275	0.777	<.001	76	view →
DLBC	DFS	Median	III,IV	0.984	0.146	<.001	69	view →
LUAD	DFS	Median	All	0.731	0.849	<.001	61	view →
PAAD	OS	Tertile	All	0.372	0.726	<.001	60	view →
KIRP	DFS	Tertile	All	0.744	0.922	<.001	53	view →
KICH	OS	Quartile	III,IV	0.159	0.837	.004	46	view →
UCEC	DFS	Tertile	All	0.713	0.572	<.001	38	view →
SKCM	OS	Tertile	III,IV	0.260	0.549	<.001	37	view →
MESO	OS	Median	III,IV	0.258	0.447	.004	28	view →
UCS	DFS	Tertile	All	0.614	0.274	.013	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

TSKU–KIRC (DFS)

Open the KIRC breakdown →